蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书Anti- Human /Mouse /Rat ERBB2 Monoclonal Antibody
Cat#:MA01760应用：WB,IHC-p,IF
| Product Name: | Phospho-ErbB 2 (Tyr1248)/ErbB 4 (Tyr1284) Recombinant Rabbit mAb |
| Cat No.: | RMA02949 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,ICC/IF,FC,IP |
| Recommended Dilution: | WB: 1:1000 ICC/IF: 1:20 FC: 1:20 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Tyr1248 of human ErbB 2 |
| Calculated Molecular Weight: | 147 kDa |
| Observed Molecular Weight: | 180 kDa |
| GenBank Accession Number: | P04626 |
| Gene ID (NCBI): | 2064 |
| Synonyms: | NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu |
| Background: | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] |
| Category: | Primary Ab |
相关产品
