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TPA Tissue Plasminogen Activator Rabbit pAb

Cat No.: DPA04471
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Product Name: TPA Tissue Plasminogen Activator Rabbit pAb
Cat No.: DPA04471
Clonality: Polyclonal
Species Reactivity: Human, Mouse, Rat
Tested Applications: WB,IHC
Recommended Dilution: WB: 1:1000-1:2000
IHC: 1:20-1:100
Size: 30ul 50ul 100uL
Format: Liquid
Source: Rabbit
Purification Method: Affinity Purification
Isotype: IgG
Conjugate: Un-conjugated
Storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a
Immunogen: A synthetic peptide of human TPA Tissue Plasminogen Activator
Calculated Molecular Weight: 63 kDa
Observed Molecular Weight: 63 kDa
GenBank Accession Number: P00750
Gene ID (NCBI): 5327
Synonyms: TPA; T-PA
Background: This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Category: Primary Ab
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