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查看说明书Recombinant Mouse AGER / RAGE Protein (His tag)
Cat#:TP07692应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | RAGE Rabbit pAb |
| Cat No.: | DPA04842 |
| Clonality: | Polyclonal |
| Species Reactivity: | Mouse, Rat |
| Tested Applications: | WB,IP |
| Recommended Dilution: | WB: 1:1000 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | Recombinant protein of mouse RAGE |
| Calculated Molecular Weight: | 43 kDa |
| Observed Molecular Weight: | 43 kDa |
| GenBank Accession Number: | Q62151 |
| Gene ID (NCBI): | 11596 |
| Synonyms: | RAGE |
| Background: | Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Can also bind oligonucleotides. Receptor for amyloid beta peptide. |
| Category: | Primary Ab |
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