蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书Bcr Rabbit pAb
Cat#:DPA02494应用：WB,IHC,ICC/IF,FC,IP
| Product Name: | Bcr Recombinant Rabbit mAb |
| Cat No.: | RMA02091 |
| Clonality: | Monoclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,IHC,ICC/IF,FC,IP |
| Recommended Dilution: | WB,IHC,ICC/IF,FC,IP |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human Bcr |
| Calculated Molecular Weight: | 143 kDa |
| Observed Molecular Weight: | 160 kDa |
| GenBank Accession Number: | P11274 |
| Gene ID (NCBI): | 613 |
| Synonyms: | ALL; CML; PHL; BCR1; D22S11; D22S662 |
| Background: | A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020] |
| Category: | Primary Ab |
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