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查看说明书Phospho-Rad17 (Ser656) Rabbit pAb
Cat#:DPA05466应用：WB,IHC,ICC/IF
| Product Name: | Phospho-Rad17 (Ser656) Rabbit pAb |
| Cat No.: | DPA05466 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,IHC,ICC/IF |
| Recommended Dilution: | WB: 1:1000-1:5000 IHC: 1:501:50 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Ser656 of human Rad17 |
| Calculated Molecular Weight: | 77 kDa |
| Observed Molecular Weight: | 80 kDa |
| GenBank Accession Number: | O75943 |
| Gene ID (NCBI): | 5884 |
| Synonyms: | CCYC; R24L; RAD24; HRAD17; RAD17SP |
| Background: | The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013] |
| Category: | Primary Ab |
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