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规格：
查看说明书Phospholamban Rabbit pAb
Cat#:DPA02795应用：WB,IHC,IP
| Product Name: | Phospho-Phospholamban (Ser16) Rabbit pAb |
| Cat No.: | DPA05498 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse |
| Tested Applications: | WB |
| Recommended Dilution: | WB: 1:2000-1:10000 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Ser16 of human Phospholamban |
| Calculated Molecular Weight: | 6 kDa |
| Observed Molecular Weight: | 12,24 kDa |
| GenBank Accession Number: | P26678 |
| Gene ID (NCBI): | 5350 |
| Synonyms: | PLB; CMD1P; CMH18 |
| Background: | The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016] |
| Category: | Primary Ab |
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