蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书Eukaryotic Cluster Of Differentiation 8a (CD8a)
Cat#:TP08581应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | Eukaryotic Cluster Of Differentiation 8a (CD8a) |
| Cat No.: | TP08581 |
| TargetID: | P01732 |
| Source: | 293F cell |
| Gene Accession Number: | 925 |
| Peptide Sequence: | Ser22~Val235 |
| Tag: | N-6His |
| Purity: | > 95% |
| Formulation: | Freeze-dried powder |
| Storage Buffer: | Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition: | Aliquot and store at -20℃ to -80℃ for up to 6 months, buffer containing 50% glycerol is recommen |
| Category: | Protein |
| Species Reactivity: | Human |
| Predicted Molecular Mass: | 30kDa |
| Applications: | Positive Control; Immunogen; SDS-PAGE; WB |
| Background: | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. |
| Size: | 10ug 50ug 100ug 200ug 1mg |
| Synonyms: | CD8;CD8 alpha;Leu-2;Leu2;MAL;p32;p32 186910 |
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