蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书Recombinant Human C-Mer Proto Oncogene Tyrosine Kinase (MERTK)
Cat#:TP05620应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | Recombinant Human MERTK / Mer Protein (His & Fc tag) |
| Cat No.: | TP08588 |
| TargetID: | Q12866 |
| Source: | HEK293 Cells |
| Gene Accession Number: | 10461 |
| Peptide Sequence: | Met 1-Ala 499 |
| Tag: | C-His & Fc |
| Purity: | >85% as determined by SDS-PAGE. |
| Formulation: | Freeze-dried powder |
| Storage Buffer: | Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition: | Aliquot and store at -20℃ to -80℃ for up to 6 months, buffer containing 50% glycerol is recommen |
| Category: | Protein |
| Species Reactivity: | Human |
| Predicted Molecular Mass: | 80 kDa |
| Applications: | Positive Control; Immunogen; SDS-PAGE; WB |
| Background: | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment |
| Size: | 10ug 50ug 100ug 200ug 1mg |
| Synonyms: | c-Eyk;c-mer;MER;RP38;Tyro12 |
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