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分子生物学Recombinant Human Transient Receptor Potential Cation Channel Subfamily V, Member 1 (TRPV1) Protein
Cat#:TP08918应用：Positive Control; Immunogen; SDS-PAGE; WB
Recombinant Human Transient Receptor Potential Cation Channel Subfamily V, Member 1 (TRPV1) Protein
Cat No.: TP08918
规格：
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| Product Name: | Recombinant Human Transient Receptor Potential Cation Channel Subfamily V, Member 1 (TRPV1) Protein |
| Cat No.: | TP08918 |
| TargetID: | Q8NER1 |
| Source: | E.coli |
| Gene Accession Number: | 7442 |
| Peptide Sequence: | Met1~Glu153 |
| Tag: | N-6His |
| Purity: | > 95% |
| Formulation: | 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. |
| Storage Buffer: | 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. |
| Storage Condition: | Aliquot and store at -20¡ãC to -80¡ãC for up to 6 months, buffer containing 7686% glycerol is recomm |
| Category: | Protein |
| Species Reactivity: | Human |
| Predicted Molecular Mass: | 24kDa |
| Applications: | Positive Control; Immunogen; SDS-PAGE; WB |
| Background: | Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca2+-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. |
| Size: | 10ug 50ug 100ug 200ug 1mg |
| Synonyms: | VR1; OTRPC1; Vanilloid Receptor Subtype 1; Capsaicin receptor; Osm-9-like TRP channel 1; Vanilloid r |
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