蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书USP13 Rabbit pAb
Cat#:DPA01343应用：WB,ICC/IF,FC,IP
| Product Name: | USP13 Rabbit pAb |
| Cat No.: | DPA01343 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse |
| Tested Applications: | WB,ICC/IF,FC,IP |
| Recommended Dilution: | WB: 1:1000-1:5000 ICC/IF: 1:20-1:50 FC: 1:100-1:500 IP: 1:20-1:50 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human USP13 |
| Calculated Molecular Weight: | 97 kDa |
| Observed Molecular Weight: | 97 kDa |
| GenBank Accession Number: | Q92995 |
| Gene ID (NCBI): | 8975 |
| Synonyms: | ISOT3; IsoT-3 |
| Background: | Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. |
| Category: | Primary Ab |
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