蛋白
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检测试剂盒
蛋白MARKER
分子生物学
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查看说明书Recombinant Interleukin 1 Beta (IL1b)
Cat#:TP02595应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | IL-1 beta Rabbit pAb |
| Cat No.: | DPA01732 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB |
| Recommended Dilution: | WB: 1:2000 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human IL-1 beta |
| Calculated Molecular Weight: | 31 kDa |
| Observed Molecular Weight: | 17,31 kDa |
| GenBank Accession Number: | P01584 |
| Gene ID (NCBI): | 3553 |
| Synonyms: | IL-1; IL1F2; IL1beta; IL1-BETA |
| Background: | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Patients with severe COVID-19 (Coronavirus Disease 2019) symptoms present elevated levels of pro-inflammatory cytokines such as IL-1B. SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2)-infected cells can produce elevated levels of IL-1B which strongly contributes to the immuno-mediated damage to the lungs as well as to other organs. [provided by RefSeq, Jun 2020] |
| Category: | Primary Ab |
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