Recombinant Human C2 / Complement Component 2 Protein (Fc tag)
Cat#:TP07173应用:Positive Control; Immunogen; SDS-PAGE; WB
Product Name: | C2 Rabbit pAb |
Cat No.: | DPA01850 |
Clonality: | Polyclonal |
Species Reactivity: | Human, Mouse |
Tested Applications: | WB |
Recommended Dilution: | WB: 1:1000 |
Size: | 30ul 50ul 100uL |
Format: | Liquid |
Source: | Rabbit |
Purification Method: | Affinity Purification |
Isotype: | IgG |
Conjugate: | Un-conjugated |
Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
Immunogen: | A synthetic peptide of human C2 |
Calculated Molecular Weight: | 83 kDa |
Observed Molecular Weight: | 100 kDa |
GenBank Accession Number: | P06681 |
Gene ID (NCBI): | 717 |
Synonyms: | CO2; ARMD14 |
Background: | Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009] |
Category: | Primary Ab |