蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书LATS1/WARTS Rabbit pAb
Cat#:DPA01922应用：WB,FC
| Product Name: | LATS1/WARTS Rabbit pAb |
| Cat No.: | DPA01922 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,FC |
| Recommended Dilution: | WB: 1:1000 FC: 1:50 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | Recombinant protein of human LATS1/WARTS |
| Calculated Molecular Weight: | 127 kDa |
| Observed Molecular Weight: | 140 kDa |
| GenBank Accession Number: | O95835 |
| Gene ID (NCBI): | 9113 |
| Synonyms: | wts; WARTS |
| Background: | The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017] |
| Category: | Primary Ab |
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