蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书Hamartin Rabbit pAb
Cat#:DPA01936应用：WB,IHC,FC
| Product Name: | Hamartin Rabbit pAb |
| Cat No.: | DPA01936 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,IHC,FC |
| Recommended Dilution: | WB: 1:5000 IHC: 1:20 FC: 1:200-1:1000 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human Hamartin |
| Calculated Molecular Weight: | 130 kDa |
| Observed Molecular Weight: | 150-170 kDa |
| GenBank Accession Number: | Q92574 |
| Gene ID (NCBI): | 7248 |
| Synonyms: | LAM; TSC |
| Background: | This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. [provided by RefSeq, Apr 2018] |
| Category: | Primary Ab |
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