蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书PEN2 Rabbit pAb
Cat#:DPA02344应用：WB,IHC,ICC/IF,FC
| Product Name: | PEN2 Rabbit pAb |
| Cat No.: | DPA02344 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IHC,ICC/IF,FC |
| Recommended Dilution: | WB: 1:1000 IHC: 1:50 ICC/IF: 1:50 FC: 1:20-1:100 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human PEN2 |
| Calculated Molecular Weight: | 12 kDa |
| Observed Molecular Weight: | 12 kDa |
| GenBank Accession Number: | Q9NZ42 |
| Gene ID (NCBI): | 55851 |
| Synonyms: | PEN2; PEN-2; MDS033; ACNINV2; MSTP064 |
| Background: | Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| Category: | Primary Ab |
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