蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书53BP1 Rabbit pAb
Cat#:DPA02579应用：WB,IHC,ICC/IF
| Product Name: | 53BP1 Rabbit pAb |
| Cat No.: | DPA02579 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,IHC,ICC/IF |
| Recommended Dilution: | WB: 1:2000-1:10000 IHC: 1:20 ICC/IF: 1:50 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human 53BP1 |
| Calculated Molecular Weight: | 214 kDa |
| Observed Molecular Weight: | 450 kDa |
| GenBank Accession Number: | Q12888 |
| Gene ID (NCBI): | 7158 |
| Synonyms: | TP53; p202; 53BP1; TDRD30; p53BP1 |
| Background: | This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] |
| Category: | Primary Ab |
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