蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书APAF1 Rabbit pAb
Cat#:DPA02873应用：WB,IP
| Product Name: | APAF1 Rabbit pAb |
| Cat No.: | DPA02873 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IP |
| Recommended Dilution: | WB: 1:1000 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | Recombinant protein of human APAF1 |
| Calculated Molecular Weight: | 142 kDa |
| Observed Molecular Weight: | 142 kDa |
| GenBank Accession Number: | O14727 |
| Gene ID (NCBI): | 317 |
| Synonyms: | CED4; APAF-1 |
| Background: | This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| Category: | Primary Ab |
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