蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书MRP2 Rabbit pAb
Cat#:DPA03113应用：WB,ICC/IF,FC
| Product Name: | MRP2 Rabbit pAb |
| Cat No.: | DPA03113 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,ICC/IF,FC |
| Recommended Dilution: | WB: 1:1000 ICC/IF: 1:50 FC: 1:20-1:100 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human MRP2 |
| Calculated Molecular Weight: | 174 kDa |
| Observed Molecular Weight: | >200 kDa |
| GenBank Accession Number: | Q92887 |
| Gene ID (NCBI): | 1244 |
| Synonyms: | DJS; MRP2; cMRP; ABC30; CMOAT |
| Background: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008] |
| Category: | Primary Ab |
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