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查看说明书GSDMA Rabbit pAb
Cat#:DPA02052应用：WB,IHC,IP
| Product Name: | GSDMA Rabbit pAb |
| Cat No.: | DPA03207 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB |
| Recommended Dilution: | WB: 1:1000 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | Recombinant protein of human GSDMA |
| Calculated Molecular Weight: | 49 kDa |
| Observed Molecular Weight: | 49 kDa |
| GenBank Accession Number: | Q96QA5 |
| Gene ID (NCBI): | 284110 |
| Synonyms: | GSDM; FKSG9; GSDM1 |
| Background: | May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable). |
| Category: | Primary Ab |
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