蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书Cullin 5 Rabbit pAb
Cat#:DPA03229应用：WB
| Product Name: | Cullin 5 Rabbit pAb |
| Cat No.: | DPA03229 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB |
| Recommended Dilution: | WB: 1:1000-1:5000 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | Recombinant protein of human Cullin 5 |
| Calculated Molecular Weight: | 91 kDa |
| Observed Molecular Weight: | 91 kDa |
| GenBank Accession Number: | Q93034 |
| Gene ID (NCBI): | 8065 |
| Synonyms: | CUL-5; VACM1; VACM-1 |
| Background: | Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. |
| Category: | Primary Ab |
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