蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书MDA5 Rabbit pAb
Cat#:DPA03329应用：WB,IHC,ICC/IF
| Product Name: | MDA5 Rabbit pAb |
| Cat No.: | DPA03329 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,IHC,ICC/IF |
| Recommended Dilution: | WB: 1:1000-1:5000 IHC: 1:50 ICC/IF: 1:100 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human MDA5 |
| Calculated Molecular Weight: | 117 kDa |
| Observed Molecular Weight: | 117 kDa |
| GenBank Accession Number: | Q9BYX4 |
| Gene ID (NCBI): | 64135 |
| Synonyms: | AGS7; Hlcd; MDA5; MDA-5; RLR-2; IDDM19; SGMRT1 |
| Background: | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19. [provided by RefSeq, Jul 2012] |
| Category: | Primary Ab |
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