蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书Cullin 2 Rabbit pAb
Cat#:DPA03401应用：WB,IHC,ICC/IF,FC,IP
| Product Name: | Cullin 2 Rabbit pAb |
| Cat No.: | DPA03401 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IHC,ICC/IF,FC,IP |
| Recommended Dilution: | WB: 1:1000-1:5000 IHC: 1:20 ICC/IF: 1:20 FC: 1:20 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human Cullin 2 |
| Calculated Molecular Weight: | 87 kDa |
| Observed Molecular Weight: | 87 kDa |
| GenBank Accession Number: | Q13617 |
| Gene ID (NCBI): | 8453 |
| Synonyms: | CUL2; Cullin-2 |
| Background: | Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). |
| Category: | Primary Ab |
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