蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书Recombinant Human JAML / AMICA Protein (His tag)
Cat#:TP07564应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | JAML Rabbit pAb |
| Cat No.: | DPA03765 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,FC,IP |
| Recommended Dilution: | WB: 1:1000-1:2000 FC: 1:20 IP: 1:20 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | Recombinant protein of human JAML |
| Calculated Molecular Weight: | 44 kDa |
| Observed Molecular Weight: | 60 kDa |
| GenBank Accession Number: | Q86YT9 |
| Gene ID (NCBI): | 120425 |
| Synonyms: | AMICA; Gm638; AMICA1; CREA7-1; CREA7-4 |
| Background: | Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. |
| Category: | Primary Ab |
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