蛋白
抗体
检测试剂盒
蛋白MARKER
分子生物学
规格：
查看说明书UMOD Rabbit pAb
Cat#:DPA03154应用：WB,IHC,IP
| Product Name: | Uromucoid Rabbit pAb |
| Cat No.: | DPA03886 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | WB,IHC |
| Recommended Dilution: | WB: 1:1000 IHC: 1:500 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | Recombinant protein of human Uromucoid |
| Calculated Molecular Weight: | 70 kDa |
| Observed Molecular Weight: | 115 kDa |
| GenBank Accession Number: | P07911 |
| Gene ID (NCBI): | 7369 |
| Synonyms: | THP; FJHN; HNFJ; THGP; HNFJ1; MCKD2; ADMCKD2 |
| Background: | The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| Category: | Primary Ab |
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