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查看说明书Recombinant Human NPC1 Protein (His & FLAG Tag)
Cat#:TP06704应用：Positive Control; Immunogen; SDS-PAGE; WB
| Product Name: | Niemann Pick C1 Rabbit pAb |
| Cat No.: | DPA03975 |
| Clonality: | Polyclonal |
| Species Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB,IHC,ICC/IF,FC |
| Recommended Dilution: | WB: 1:2000 IHC: 1:20 ICC/IF: 1:20 FC: 1:50 |
| Size: | 30ul 50ul 100uL |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Un-conjugated |
| Storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide a |
| Immunogen: | A synthetic peptide of human Niemann Pick C1 |
| Calculated Molecular Weight: | 142 kDa |
| Observed Molecular Weight: | 160-180 kDa |
| GenBank Accession Number: | O15118 |
| Gene ID (NCBI): | 4864 |
| Synonyms: | NPC |
| Background: | This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009] |
| Category: | Primary Ab |
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